发明名称 |
Charged mesoporous silica nanoparticle-based drug delivery system for controlled release and enhanced bioavailability |
摘要 |
A charged mesoporous silica nanoparticle (MSN)-based drug delivery system for controlled release and enhanced bioavailability is disclosed. The system comprises a positively charged MSN, which has a silica matrix and an array of pores and/or nanochannels in the matrix. The entire substance of the matrix, all the surfaces and the pores and/or nanochannels comprise a plurality of silanol (Si—OH) and quaternary ammonium functional groups. The bioavailability of a negatively charged bioactive compound can be increased by loading it into the pores and/or nanochannels. The silanol (Si—OH) functional groups on the surfaces lining the walls of the pores and/or nanochannels are free to deprotonate in a fluid having pH above the pI of the positively charged MSN and lead to a sustained release of the negatively charged drug from the pores and/or nanochannels, and thereby enhance the bioavailability of the drug. |
申请公布号 |
US8252337(B2) |
申请公布日期 |
2012.08.28 |
申请号 |
US20090581965 |
申请日期 |
2009.10.20 |
申请人 |
LEE CHIA-HUNG;LO LEU-WEI;YANG CHUNG-SHI;MOU CHUNG-YUAN;NATIONAL HEALTH RESEARCH INSTITUTES |
发明人 |
LEE CHIA-HUNG;LO LEU-WEI;YANG CHUNG-SHI;MOU CHUNG-YUAN |
分类号 |
A61K9/14;A61K47/18 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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