发明名称 |
Antibodies against human IL33R and uses thereof |
摘要 |
An antibody binding to IL33R characterized in that the heavy chain variable domain comprises a CDR3 region of SEQ ID NO:1, a CDR2 region of SEQ ID NO:2 and a CDR1 region of SEQ ID NO:3 and in that the light chain variable domain comprises a CDR3 region of SEQ ID NO:4, a CDR2 region of SEQ ID NO:5 and a CDR1 region of SEQ ID NO:6 or a chimeric, humanized or T cell epitope depleted antibody variant thereof has advantageous properties for the treatment of inflammatory diseases. |
申请公布号 |
US2012213774(A1) |
申请公布日期 |
2012.08.23 |
申请号 |
US201213402399 |
申请日期 |
2012.02.22 |
申请人 |
FERTIG GEORG;FISCHER JENS;GEORGES GUY;KALUZA KLAUS;LIFKE VALERIA;MOELLEKEN JOERG;OFFNER SONJA;PASHINE ACHAL;SEEBER STEFAN;HOFFMANN-LA ROCHE INC. |
发明人 |
FERTIG GEORG;FISCHER JENS;GEORGES GUY;KALUZA KLAUS;LIFKE VALERIA;MOELLEKEN JOERG;OFFNER SONJA;PASHINE ACHAL;SEEBER STEFAN |
分类号 |
A61K39/395;A61P1/04;A61P11/06;A61P19/02;C07K16/24;C12N1/19;C12N1/21;C12N5/10;C12N15/13;C12N15/63;C12P21/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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