发明名称 |
COMPOUNDS AND METHODS OF TREATING HYPERTENSION |
摘要 |
<p>Hydrogenated pyrido[4,3-b]indoles, pyrido [3, 4-b] indoles and azepino[4,5-b]indoles are described. The compounds may bind to and are adrenergic receptor a2B antagonists. The compounds may also bind to and antagonize adrenergic receptor a2B.The compounds may find use in therapy, e.g., to (i) reduce blood pressure and/or (ii) promote renal blood flow and/or (iii) decrease or inhibit sodium reabsorption. The compounds may also be used to treat diseases or conditions that are, or are expected to be, responsive to a decrease in blood pressure. Use of the compounds to treat cardiovascular and renal disorders is particularly described.</p> |
申请公布号 |
WO2012112961(A1) |
申请公布日期 |
2012.08.23 |
申请号 |
WO2012US25750 |
申请日期 |
2012.02.17 |
申请人 |
MEDIVATION TECHNOLOGIES, INC.;PROTTER, ANDREW, ASHER;CHAKRAVARTY, SARVAJIT |
发明人 |
PROTTER, ANDREW, ASHER;CHAKRAVARTY, SARVAJIT |
分类号 |
A61K31/55;C07D471/00 |
主分类号 |
A61K31/55 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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