发明名称 |
ROTHIA SPECIES GLUTEN-DEGRADING ENZYMES AND USES THEREOF |
摘要 |
There are gluten-degrading enzymes found in Rothia species bacteria that are capable of breaking peptide bonds in -XPQ-, -QQP-, -PPF-, -LYP- and/or -PFP-containing peptides. These enzymes are acidic enzymes; they retain protease activity at acidic pH, eg., at 3.0, and have isoelectric points in a pH range of 2.0-7.0. Embodiments herein provide isolated enzyme compositions and probiotic compositions comprising at least one acidic gluten-degrading enzyme or a Rothia species bacteria. Also provided herein are methods of treatment of celiac disease or a related disorder, treatment of gluten-containing foodstuff, degrading and/or detoxifying gluten comprising the acidic gluten-degrading enzyme and/or compositions. |
申请公布号 |
WO2012006384(A9) |
申请公布日期 |
2012.08.23 |
申请号 |
WO2011US43118 |
申请日期 |
2011.07.07 |
申请人 |
TRUSTEES OF BOSTON UNIVERSITY;HELMERHORST, EVA J.;OPPENHEIM, FRANK G. |
发明人 |
HELMERHORST, EVA J.;OPPENHEIM, FRANK G. |
分类号 |
C12N9/52;A61K38/16;A61K38/48;A61P37/08;C07K14/195 |
主分类号 |
C12N9/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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