发明名称 |
Molecular Predictors of Therapeutic Response to Specific Anti-Cancer Agents |
摘要 |
Herein is described the use of a collection of 50 breast cancer cell lines to match responses to 77 conventional and experimental therapeutic agents with transcriptional, proteomic and genomic subtypes found in primary tumors. Almost all compounds produced strong differential responses across the cell lines produced responses that were associated with transcriptional and proteomic subtypes and produced responses that were associated with recurrent genome copy number abnormalities. These associations can now be incorporated into clinical trials that test subtype markers and clinical responses simultaneously.
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申请公布号 |
US2012214829(A1) |
申请公布日期 |
2012.08.23 |
申请号 |
US201213401780 |
申请日期 |
2012.02.21 |
申请人 |
SPELLMAN PAUL T.;GRAY JOE W.;SADANANDAM ANGURAJ;HEISER LAURA M.;GIBB WILLIAM J.;KUO WEN-LIN;WANG NICHOLAS J.;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
SPELLMAN PAUL T.;GRAY JOE W.;SADANANDAM ANGURAJ;HEISER LAURA M.;GIBB WILLIAM J.;KUO WEN-LIN;WANG NICHOLAS J. |
分类号 |
A61K31/517;A61K31/165;A61K31/167;A61K31/437;A61K31/513;A61P35/00;C12Q1/02;C12Q1/68;C40B30/00;G01N33/566 |
主分类号 |
A61K31/517 |
代理机构 |
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代理人 |
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地址 |
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