发明名称 |
Pentose phosphate pathway upregulation to increase production of non-native products of interest in transgenic microorganisms |
摘要 |
Coordinately regulated over-expression of the genes encoding glucose 6-phosphate dehydrogenase ["G6PDH"] and 6-phospho-gluconolactonase ["6PGL"] in transgenic strains of the oleaginous yeast, , comprising a functional polyunsaturated fatty acid ["PUFA"] biosynthetic pathway, resulted in increased production of PUFAs and increased total lipid content in the cells. This is achieved by increased cellular availability of the reduced form of nicotinamide adenine dinucleotide phosphate ["NADPH"], an important reducing equivalent for reductive biosynthetic reactions, within the transgenic microorganism. |
申请公布号 |
AU2011235307(A1) |
申请公布日期 |
2012.08.23 |
申请号 |
AU20110235307 |
申请日期 |
2011.03.29 |
申请人 |
E. I. DU PONT DE NEMOURS AND COMPANY |
发明人 |
HONG, SEUNG-PYO;XUE, ZHIXIONG;ZHU, QUINN QUN |
分类号 |
C12P1/00;C12N1/00;C12N1/13;C12N1/15;C12N1/19 |
主分类号 |
C12P1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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