发明名称 |
4-AMINOALCOHOLQUINOLINE DERIVATIVES, ENANTIOSELECTIVE SYNTHESIS METHODS AND THE USE THEREOF |
摘要 |
The present invention is intended to provide new antimalarial compounds with a strong antimalarial activity as well as antibacterial activity with few neurological side effects and a new enantioselective pathway to mefloquine amino-analogs allowing the access of such compounds. The present invention relates to new 4 -aminoalcohol quinoline derivatives of formula (I), as well as the synthesis methods and the uses of such derivatives. In which Y is one selected from formulae (II) to (III). In which Z is selected from formulae (IV) to (VI), and wherein R1, R2, R3, R4, R5, R6, R7 and n are as defined in the claims. |
申请公布号 |
WO2012107532(A1) |
申请公布日期 |
2012.08.16 |
申请号 |
WO2012EP52240 |
申请日期 |
2012.02.09 |
申请人 |
UNIVERSITE DE PICARDIE JULES VERNE;JONET, ALEXIA;DASSONVILLE-KLIMPT, ALEXANDRA;MULLIE, CATHERINE;TAUDON, NICOLAS;SONNET, PASCAL |
发明人 |
JONET, ALEXIA;DASSONVILLE-KLIMPT, ALEXANDRA;MULLIE, CATHERINE;TAUDON, NICOLAS;SONNET, PASCAL |
分类号 |
C07D215/14;A61K31/47;A61P31/04;A61P33/06 |
主分类号 |
C07D215/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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