发明名称 |
Chemokine-Mucin Fusions Linked to Glycosylphosphatidylinositol (GPI)-Anchors in Tissue Regeneration and as Tumour Immune Adjuvants |
摘要 |
The present invention relates to chemokine-mucin fusions linked to glycosylphosphatidylinositol (GPI)-anchors and their use as anti-cancer adjuvants and as agents in tissue regeneration and suppression of vascular damage. GPI-linked chemokines are incorporated in the surface membrane of tumour cells and effect a recruitment of cytotoxic immune cells to the tumour site following injection in vivo. Leukocytes, cytotoxic T-cells and NK cells target the chemokine-GPI-anchored tumour cells and modulate cell-mediated lysis of the tumour cells. The efficiency of GPI-anchoring and modulation of immune cells can be further enhanced by linking the chemokine to a mucin domain followed by the GPI-anchor. The GPI-anchored chemokines, with or without mucin domain, are remarkably useful for the inhibition of tumour growth, tissue regeneration, and suppression of acute vascular damage to allografts. |
申请公布号 |
US2012208769(A1) |
申请公布日期 |
2012.08.16 |
申请号 |
US20060085882 |
申请日期 |
2006.11.30 |
申请人 |
NELSON PETER JON;HUSS RALF;GRONE HERMANN-JOSEF |
发明人 |
NELSON PETER JON;HUSS RALF;GRONE HERMANN-JOSEF |
分类号 |
A61K38/19;A61K31/711;A61P35/00;C07K19/00;C12N1/21;C12N5/02;C12N5/10;C12N15/62;C12N15/63 |
主分类号 |
A61K38/19 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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