发明名称 |
B-TYPE PLEXIN ANTAGONISTS AND USES THEREOF |
摘要 |
The present invention concerns the field of cancer therapy. In particular, it relates to an antagonist of a B-type plexin which prevents the interaction of the B-type plexin with ErbB-2 for use as a medicament, in particular, for treating metastasizing cancer. The present invention also contemplates a method for identifying an antagonist which prevents the interaction of a B-type plexin with ErbB-2. Finally, the invention provides for a polynucleotide encoding a B-type plexin polypeptide which lacks a functional intracellular domain and the said polypeptide. |
申请公布号 |
CA2827017(A1) |
申请公布日期 |
2012.08.16 |
申请号 |
CA20122827017 |
申请日期 |
2012.02.09 |
申请人 |
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V.;RUPRECHT-KARLS-UNIVERISTAT HEIDELBERG |
发明人 |
OFFERMANNS, STEFAN;SWIERCZ, JAKUB;WORZFELD, THOMAS |
分类号 |
C12N15/113;A61K31/713;A61K39/395;A61P35/04;C07K16/30 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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