| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide new compounds for inducing dedifferentiation of mammalian cells into multipotent stem cells, pharmaceutical compositions, and methods for inducing dedifferentiation. <P>SOLUTION: There are provided: the compounds of chemical formula I (wherein R<SP POS="POST">1</SP>represents 3-chlorophenyl, 4-dimethylaminophenyl, 2-pyridyl, 6-quinolyl or the like; and R<SP POS="POST">2</SP>represents cyclohexylmethylamino, cyclohexylamino, phenylsulfonyl or the like), the pharmaceutical compositions containing the compounds, and the methods for inducing dedifferentiation of lineage committed cells, including a step of bringing an isolated lineage committed mammalian cell into contact with the compound to cause the mammalian cell to dedifferentiate into the multipotent stem cell. <P>COPYRIGHT: (C)2012,JPO&INPIT |
