发明名称 |
INNATE IMMUNE SUPPRESSION ENABLES REPEATED DELIVERY OF LONG RNA MOLECULES |
摘要 |
The present invention relates in part to methods for suppressing the innate immune response of a cell to transfection with an exogenous nucleic acid, to methods for increasing expression of a protein encoded by an exogenous nucleic acid by repeated delivery of the exogenous nucleic acid to a cell, and to methods of changing the phenotype of a cell by differentiating, transdifferentiating or dedifferentiating cells by repeatedly delivering one or more nucleic acids that encode defined proteins. A method is provided for extended transient transfection by repeated delivery of an in vitro-transcribed RNA (“ivT-RNA”) to a cell to achieve a high and sustained level of expression of a protein encoded by an ivT-RNA transcripts. |
申请公布号 |
US2012208278(A1) |
申请公布日期 |
2012.08.16 |
申请号 |
US201213455327 |
申请日期 |
2012.04.25 |
申请人 |
YANIK MEHMET FATIH;ANGEL MATTHEW;MASSACHUSETTS INSTITUTE OF TECHNOLOGY |
发明人 |
YANIK MEHMET FATIH;ANGEL MATTHEW |
分类号 |
C12N15/85;C12N5/071;C12N5/10;C12N13/00 |
主分类号 |
C12N15/85 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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