发明名称 FLUORESCENT CELL LINE mel Kor-TurboRFP AND METHOD FOR USING IT FOR IN VITRO STUDIES IN EXPERIMENTAL ONCOLOGY
摘要 FIELD: medicine. ^ SUBSTANCE: human melanoma cell line mel Kor-TurboRFP possess the stable cultural and morphological characteristics. The cell line is characterised by the expression of melanoma (differentiation) markers -CD63, HMB45, MelanA, Tyrozinase, the absence of class one and two histocompatibility antigens. The cell line is characterised by the expression of red fluorescent protein TurboRFP. The survivor tumour cell count is evaluated after the effect of anti-cancer preparations by measuring the intrinsic fluorescence intensity of the cells mel Kor-TurboRFP in microplate wells. ^ EFFECT: invention provides higher efficacy and reliability of investigations of anti-cancer preparations. ^ 2 cl, 9 dwg, 3 ex
申请公布号 RU2458123(C2) 申请公布日期 2012.08.10
申请号 RU20090137826 申请日期 2009.10.13
申请人 UCHREZHDENIE ROSSIJSKOJ AKADEMII NAUK INSTITUT BIOKHIMII IM. A.N. BAKHA RAN 发明人 MEEROVICH IRINA GENNAD'EVNA;ZHERDEVA VIKTORIJA VJACHESLAVOVNA;ARSLANBAEVA LJAJSAN RAVILOVNA;SAVITSKIJ ALEKSANDR PAVLOVICH;BUROVA OL'GA SEMENOVNA;MIKHAJLOVA IRINA NIKOLAEVNA;MOROZOVA LIDIJA FEDOROVNA;BARYSHNIKOV ANATOLIJ JUR'EVICH
分类号 C12N5/09 主分类号 C12N5/09
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