发明名称 |
UNIVERSAL ANTI-TAG CHIMERIC ANTIGEN RECEPTOR-EXPRESSING T CELLS AND METHODS OF TREATING CANCER |
摘要 |
The present invention provides a universal, yet adaptable, anti-tag chimeric antigen receptor (AT-CAR) system which provides T cells with the ability and specificity to recognize and kill target cells, such as tumor cells, that have been marked by tagged antibodies. As an example, αFITC-CAR-expressing T cells have been developed that specifically recognize various human cancer cells when those cells are bound by cancer-reactive FITC-labeled antibodies. The activation of αFITC-CAR-expressing T cells is shown to induce efficient target lysis, T cell proliferation, and cytokine/chemokine production. The system can be used to treating subjects having cancer. |
申请公布号 |
WO2012082841(A9) |
申请公布日期 |
2012.08.09 |
申请号 |
WO2011US64808 |
申请日期 |
2011.12.14 |
申请人 |
UNIVERSITY OF MARYLAND, BALTIMORE;DAVILA, EDUARDO;TAMADA, KOJI |
发明人 |
DAVILA, EDUARDO;TAMADA, KOJI |
分类号 |
A61K39/395;A61K31/4188;A61P35/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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