BIFUNCTIONAL ANTI-PLATELET AGGREGATION MEDICAMENT AND USES THEREOF

摘要

The present invention belongs to the technical field of pharmaceuticals. Disclosed are a bifunctional anti-platelet aggregation medicament represented by formula (I) and its uses for preventing and treating arterial thrombotic diseases. The medicament of the present invention has P2Y12 receptor-antagonist activity and phosphodiesterase-inhibiting activity at the same time. The anti-platelet mechanism of the medicament is provided by the experimental results of anti-platelet aggregation activity in vivo and in vitro. The structure and anti-platelet mechanism of the medicament are different from known anti-platelet medicaments Aspirin, Clopidogrel, Prasugrel, Cilostazol and platelet fibrinogen receptor antagonist. The medicament of the present invention shows good inhibiting effects on platelet aggregation induced by many kinds of agonists. The experimental results of the arterial thrombotic model of mice in vivo shows that the medicament has excellent anti-thrombus activity similar to Clopidogrel without any obvious side-effect of bleeding. The medicament of the present invention can be used as anti-thrombus medicines for treating arterial thrombotic diseases such as coronary heart disease, stroke, and so on. Said formula (I) is as follows.