发明名称 |
METHODS AND COMPOSITIONS TO SUPPORT TRANSPLANTED TISSUE INTEGRATION AND INNOSCULATION WITH ADIPOSE STROMAL CELLS |
摘要 |
The present invention generally relates to methods, compositions and uses thereof for enhancing vascularization of a tissue or cell transplant for transplantation into a subject. In particular, one aspect of the present invention provides methods and compositions comprising the use of a population of stromal vascular fraction (SVF) cells to encapsulate or surround a tissue or cell transplant to enhance vascularization of the tissue or cell transplant. Another aspect of the present invention provides methods and compositions for enhancing vascularization of a tissue or cell transplant by combining a population of SVF cells with a tissue or cell transplant to form a transplant mixed with SVF cells. In some embodiments, the SVF cells can be on the surface or embedded within a three-dimensional matrix. In some embodiments, the SVF cells can be generically engineered to secrete therapeutic proteins or pro-angiogenic factors. |
申请公布号 |
US2012201890(A1) |
申请公布日期 |
2012.08.09 |
申请号 |
US201013502090 |
申请日期 |
2010.10.13 |
申请人 |
WILLIAMS STUART K.;HOYING JAMES BEATLY;KRISHNAN LAXMINARAYANAN;UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. |
发明人 |
WILLIAMS STUART K.;HOYING JAMES BEATLY;KRISHNAN LAXMINARAYANAN |
分类号 |
A61K9/00;A61K35/12;A61P41/00 |
主分类号 |
A61K9/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|