TUMOR TISSUE-SELECTIVE BIO-IMAGING NANOPARTICLES

摘要

PURPOSE: A bio-imaging nanoparticle is provided to ensure excellent water solubility, target selectivity, and bio affinity and to early diagnose diseases. CONSTITUTION: A bio-imaging nanoparticle contains: a core nanoparticle; a binding layer which contains organic ligand(20), surfactant(14) and a polyoxyalkylene derivative(16) of fatty acid ester and covers the core nanoparticle; and a functional molecule(18). The organic ligand is conjugated on the surface of the core nanoparticle. The surfactant is conjugated on a part of the surface, in which organic ligand is not conjugated. The core nanoparticle contains a core(10) and a shell(12). The functional molecule is a bio affinity molecule, target-oriented molecule, or a conjugate or mixture thereof.