发明名称 |
Pharmaceutical compositions for reducing amyloid deposition, amyloid neurotoxicity, and microgliosis |
摘要 |
The present invention provides methods for reducing A&bgr; deposition, A&bgr; neurotoxicity and microgliosis in an animal or human afflicted with a cerebral amyloidogenic disease, such as Alzheimer's disease (AD), by administering therapeutically effective amounts of the (R)-enantiomer of the dihydropyridine compound nilvadipine, also known as (−)-nilvadipine, to the animal or human. Further provided are methods for reducing the risk of A&bgr; deposition, A&bgr; neurotoxicity and microgliosis in animals or humans suffering from traumatic brain injury by administering (−)-nilvadipine after the traumatic brain injury and continuing treatment for a prescribed period of time thereafter. |
申请公布号 |
US8236347(B2) |
申请公布日期 |
2012.08.07 |
申请号 |
US20100697436 |
申请日期 |
2010.02.01 |
申请人 |
MULLAN MICHAEL J.;PARIS DANIEL;IVEY, III ROBERT A.;ALZHEIMER'S INSTITUTE OF AMERICA, INC. |
发明人 |
MULLAN MICHAEL J.;PARIS DANIEL;IVEY, III ROBERT A. |
分类号 |
A61K9/64;A61K31/44 |
主分类号 |
A61K9/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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