| 摘要 |
Cells reprogrammed with oncogenic factors (CROFs) include incorrectly programmed stem cells such as induced pluripotent stem cells (iPSCs). The present application discloses linkages between iPS reprogramming and its potential roles in neoplastic transformation and thus establishes a foundation for using iPSCs as a class of CROFs for screening anti-neoplastic agents. The screening process involves examining the capability of a single agent or a combination of multiple agents in suppressing a neoplastic process including aerobic glycolysis and the related anabolism and thus inhibiting excessive reproduction of the neoplastic cell. In addition, agents are also screened for their potential in inhibiting invasion and migration of neoplastic cells. Anti-neoplastic agents found through methods disclosed here may represent wide-spectrum anti-neoplastic agents but possess very limited side effect because they target at one or more unique aspects of neoplastic processes, rather than affecting one or more living processes common to all cells including normal cells.
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