发明名称 |
ASSAYS, METHODS AND KITS FOR PREDICTING RENAL DISEASE AND PERSONALIZED TREATMENT STRATEGIES |
摘要 |
Assays, methods and kits for predicting a subject's (e.g., human) risk of primary glomerulopathy, secondary glomerulopathy or recurrence (e.g., post-transplant recurrence) of any glomerular disease include examining cells for the presence or absence of cytoskeletal disruptions or rearrangements and examining cells for modulation of expression and/or activity of markers such as SMPDL-3b. Assays for predicting if a diabetic subject will develop kidney disease or a patient with FSGS will develop recurrent disease after transplant also include examining cells for the presence or absence of cytoskeletal disruptions or rearrangements and examining cells for modulation of expression and/or activity of markers such as SMPDL-3b. Also described herein are compositions and methods for treating and preventing the aforementioned disorders. |
申请公布号 |
WO2012054321(A3) |
申请公布日期 |
2012.08.02 |
申请号 |
WO2011US56272 |
申请日期 |
2011.10.14 |
申请人 |
UNIVERSITY OF MIAMI;FORNONI, ALESSIA;BURKE, GEORGE WILLIAM;MERSCHER-GOMEZ, SANDRA |
发明人 |
FORNONI, ALESSIA;BURKE, GEORGE WILLIAM;MERSCHER-GOMEZ, SANDRA |
分类号 |
A01N63/00;A01N65/00;G01N1/30;G01N33/48 |
主分类号 |
A01N63/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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