发明名称 |
Therapeutic and Diagnostic Molecules |
摘要 |
The present invention relates to methods for modulating angiogenesis, comprising administering to a subject, or cells or tissue derived therefrom: (i) one or more miRNA, or precursors or variants thereof, wherein at least one of said miRNA comprises a seed region comprising the sequence UCACAGU (SEQ ID NO:37) to inhibit angiogenesis; or (ii) one or more antagonists of a miRNA, wherein said miRNA comprises a seed region comprising the sequence UCACAGU (SEQ ID NO:37) to promote or induce angiogenesis. Also provided are methods of diagnosis of conditions associated with abnormal angiogenesis, or determining predisposition thereto. Suitable pharmaceutical compositions are also provided.
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申请公布号 |
US2012196925(A1) |
申请公布日期 |
2012.08.02 |
申请号 |
US201013376304 |
申请日期 |
2010.06.04 |
申请人 |
GAMBLE JENNIFER;VADAS MATHEW;GOODALL GREGORY;YOUNG JENNIFER;CENTENARY INSTITUTE OF CANCER MEDICINE AND CELL BIOLOGY;WENKART FOUNDATION;MEDVET SCIENCE PTY LTD.;UNIVERSITY OF SYDNEY |
发明人 |
GAMBLE JENNIFER;VADAS MATHEW;GOODALL GREGORY;YOUNG JENNIFER |
分类号 |
A61K31/7105;A61P1/00;A61P3/00;A61P9/00;A61P9/10;A61P15/00;A61P15/08;A61P17/02;A61P17/06;A61P25/00;A61P27/02;A61P27/06;A61P29/00;A61P35/00;C12Q1/68;C40B30/04 |
主分类号 |
A61K31/7105 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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