发明名称 |
AMELIORATION OF METABOLIC SYNDROME OR METHOD FOR SCREENING FOR AMELIORATING AGENT FOR METABOLIC SYNDROME UTILIZING PHYSIOLOGICAL FUNCTION OF SPHINGOMYELIN SYNTHASE SMS2 |
摘要 |
<p>Disclosed is a method for screening for a medicinal agent that can decrease a body weight, a medicinal agent that can reduce a visceral fat, a medicinal agent that can reduce a triglyceride in the liver, and a medicinal agent that can ameliorate obesity and fatty liver. The method involves a step of measuring the inhibitory activity of a candidate substance on a sphingomyelin synthase, wherein the candidate substance is determined to have at least one function selected from the group consisting of an anti-obesity agent, a visceral fat-reducing agent, a fatty liver-treating agent and an adiponectin expression enhancer when the candidate substance has an inhibitory activity on the sphingomyelin synthase.</p> |
申请公布号 |
EP2481808(A1) |
申请公布日期 |
2012.08.01 |
申请号 |
EP20100818555 |
申请日期 |
2010.09.22 |
申请人 |
NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY;SHIONOGI & CO., LTD. |
发明人 |
MITSUTAKE, SUSUMU;IGARASHI, YASUYUKI;ZAMA, KOTA;YOSHIDA, TETSUYA;TANAKA, YOSHIKAZU;TAKEMOTO, HIROSHI |
分类号 |
C12Q1/48;C12N5/10;C12N15/09;G01N33/15;G01N33/50;G01N33/68 |
主分类号 |
C12Q1/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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