发明名称 |
PEPTIDOMIMETIC MACROCYCLES |
摘要 |
<p>Disclosed are peptidomimetic macrocycles comprising a helix, such as an alpha helix, and methods of using such macrocycles for the treatment of disease such as cancer. In other aspects, the peptidomimetic macrocycle comprises an a,a-disubstituted amino acid, or may comprise a crosslinker linking the a-positions of at least two amino acids or at least one of said two amino acids may be an a,a-disubstituted amino acid. Further included is the targeting of components of the Wnt signaling pathway such as the Tcf4-/3-catenin complex.</p> |
申请公布号 |
EP2480565(A1) |
申请公布日期 |
2012.08.01 |
申请号 |
EP20100819418 |
申请日期 |
2010.09.22 |
申请人 |
AILERON THERAPEUTICS, INC. |
发明人 |
NASH, HUW, M.;KAPELLER-LIBERMANN, ROSANA;HAN, JIA-WEN;SAWYER, TOMI, K.;NOEHRE, JUSTIN;KAWAHATA, NORIYUKI |
分类号 |
C07K7/50;A61K38/12;C07K7/64;C07K14/47 |
主分类号 |
C07K7/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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