发明名称 BIOSYNTHESIS OF CMP-LEGIONAMINIC ACID FROM FRUCTOSE-6-P, AND RESPECTIVE PATHWAY INTERMEDIATES, USING NOVEL GDP-LINKED PRECURSORS
摘要 <p>The sialic acid-like sugar legionaminic acid is found as a virulence-associated surface glyco-conjugate in Legionella pneumophila and Campylobacter coli. In this work, we have purified and biochemically characterized eleven candidate biosynthetic enzymes from C. jejuni, thereby fully reconstituting the biosynthesis of legionaminic acid and its CMP-activated form, starting from fructose-6-P. This pathway involves unique GDP-linked intermediates and provides a facile means for the efficient large-scale synthesis of an important sialic acid mimic and novel precursors.</p>
申请公布号 EP2379735(A4) 申请公布日期 2012.08.01
申请号 EP20090832761 申请日期 2009.12.16
申请人 NATIONAL RESEARCH COUNCIL OF CANADA 发明人 SCHOENHOFEN, IAN, C.;LOGAN, SUSAN, M.
分类号 C12P19/28;C07H19/16;C12P19/30;C12P19/32 主分类号 C12P19/28
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