摘要 |
<p>The present invention relates to 2-Amino-5,5-difluoro-5,6-dihydro-4H-[1,3]oxazin-4-yl)- phenyl]-amide derivatives of formula (I) having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.</p> |
申请人 |
F. HOFFMANN-LA ROCHE AG;SIENA BIOTECH S.P.A. |
发明人 |
BANNER, DAVID;GUBA, WOLFGANG;HILPERT, HANS;MAUSER, HARALD;MAYWEG, ALEXANDER, V.;NARQUIZIAN, ROBERT;PINARD, EMMANUEL;POWER, EOIN;ROGERS-EVANS, MARK;WOLTERING, THOMAS;WOSTL, WOLFGANG |