发明名称 |
IMMUNOGENIC COMPOSITION COMPRISING VARIANTS OF STAPHYLOCOCCAL CLUMPING FACTOR A |
摘要 |
The present invention relates to ClfA polypeptides wherein amino acid Y474 or an amino acid adjacent to Y474 is mutated such that fibrinogen binding activity is decreased compared to an equivalent ClfA polypeptide without mutation of Y474 or an amino acid adjacent to Y474 as well as immunogenic compositions, vaccines, processes and uses of such mutated ClfA polypeptides.
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申请公布号 |
US2012189650(A1) |
申请公布日期 |
2012.07.26 |
申请号 |
US201013388715 |
申请日期 |
2010.08.03 |
申请人 |
DEQUESNE GUY;GERMAIN SOPHIE MARIE JEANNE VALENTINE |
发明人 |
DEQUESNE GUY;GERMAIN SOPHIE MARIE JEANNE VALENTINE |
分类号 |
A61K39/085;A61P31/04;A61P37/04;C07K14/31;C12N15/31 |
主分类号 |
A61K39/085 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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