HIV inhibiting 5-substituted pyrimidines

摘要

HIV replication inhibitors of formula (I) a -oxide, a pharmaceutically acceptable addition salt, a quaternary amine or a stereochemically isomeric form thereof, wherein A is -CH-CH- , -CH=CH- , -C≡C- ; R is hydrogen, aryl, formyl, Calkylcarbonyl, Calkyl, Calkyloxycarbonyl, Rhydroxy, halo, Calkyl, carboxyl, cyano, -C(=O)R, nitro, amino, mono- or di(Calkyl)amino, polyhalomethyl; X is -NR-, -O-, -S-, -S(=O); R is H, Calkyl, halo ; R is H, Calkyl, halo ; R is nitro, amino, mono- and diCalkylamino, aryl, halo, -CHO, -CO-R, -COOR, -NH-C(=O)H, -NH-C(=O)R, -CH=N-O-R; R is Calkyl, amino, mono- or di(Calkyl)amino or polyhaloCalkyl; R is hydrogen, Calkyl, arylCalkyl; R is hydrogen, Calkyl, aryl; p is 1 or 2; aryl is optionally substituted phenyl; pharmaceutical compositions containing these compounds as active ingredient and processes for preparing said compounds and compositions.