发明名称 |
2-PYRIDINECARBOXAMIDE DERIVATIVE HAVING GK-ACTIVATING ACTIVITY |
摘要 |
<p>Provided are a compound of a formula (I) and its pharmaceutically-acceptable salt, which have a glucokinase-activating effect and are therefore useful for treatment of diabetes and obesity.
[In the formula, R 1 and R 2 each independently represent a lower alkyl group; X 1 represent a group of a formula (II-1):
(wherein R 1 and R 12 each independently represent a hydrogen atom or a lower alkyl group, or taken together with the nitrogen atom to which they are attached, R 1 and R 12 may form a 4- to 7-membered nitrogen-containing aliphatic ring (one carbon atom constituting the 4- to 7-membered nitrogen-containing aliphatic ring may be replaced by an oxygen atom), or taken together with a carbon atom in (CH 2 ) m , R 11 and R 12 may form a 4- to 7-membered nitrogen-containing aliphatic ring; m indicates an integer of from 1 to 3).]</p> |
申请公布号 |
EP2077266(B1) |
申请公布日期 |
2012.07.25 |
申请号 |
EP20070829750 |
申请日期 |
2007.10.05 |
申请人 |
MSD K.K. |
发明人 |
HASHIMOTO, NORIAKI;SAGARA, YUFU;ASAI, MASANORI;NISHIMURA, TERUYUKI |
分类号 |
C07D417/14;A61K31/155;A61K31/4439;A61K31/4545;A61K31/5377;A61K38/00;A61K38/28;A61K45/00;A61P3/04;A61P3/10;A61P43/00 |
主分类号 |
C07D417/14 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|