Combination of syrosingopine and a biguanide

摘要

A pharmaceutical composition comprises a combination of syrosingopine and a biguanide, in particular metformin wherein preferably the relative amount (w/w) of syrosingopine and metformin is between 1 to 10 and 1 to 1000. The biguanides are preferably selected from metformin, phenformin or buformin. Exemplified combinations include syrosingopine and metformin and syrosingopine and phenformin for use in the treatment of cancer and immunosuppression in the treatment of autoimmune diseases. The syrosingopine and biguanide may be administered in the same or in different compositions.