Methods and compositions for enhancing the viability of microneedle pores

摘要

Described herein is a method of transdermally administering one or more pharmaceutically active agents to a mammal The method comprises administering one or more active pharmaceutical agents to the skm of the subject, in conjunction with microneedles and one or more COX inhibitors, whereby the COX inhibitors facilitate the absorption of the active pharmaceutical agents by prolonging the pore opening created by the application of the microneedle