发明名称 |
Methods for inducing differentiation of undifferentiated mammalian cells into osteoblasts |
摘要 |
<p>The present invention provides methods for inducing differentiation of undifferentiated mammalian cells into osteoblasts, and methods for identifying a compound that induces differentiation of undifferentiated mammalian cells into osteoblasts. In addition, the present invention provides polynucleotides and vectors, and the use thereof as a medicament for the treatment of a disease involving a systemic or local decrease in mean bone density. Moreover, the present invention provides methods for in vitro production of bone tissue, osteoblast cells and methods for diagnosing a pathological condition involving a systemic or local decrease in mean bone density or a susceptibility to the condition.
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申请公布号 |
EP2248898(A3) |
申请公布日期 |
2012.07.25 |
申请号 |
EP20100174538 |
申请日期 |
2004.12.29 |
申请人 |
GALAPAGOS N.V. |
发明人 |
VAN ROMPAEY, LUC JULIAAN CORINA;TOMME, PETER HERWIG MARIA;BROWN, ROBIN JOHN |
分类号 |
C12N15/113;A61K31/713;A61P19/08;A61P19/10;C12N5/077;C12N5/10;C12Q1/68;G01N33/68 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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