发明名称 Substituted piperidine spiro pyrrolidinone and piperidinone, preparation and therapeutic use thereof
摘要 The present disclosure relates to a series of substituted N-phenyl-bipyrrolidine carboxamides of formula (I). wherein R1, R2, R3, m, n and p are as described herein. More specifically, the compounds of this invention are modulators of H3 receptors and are, therefore, useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases modulated by H3 receptors including diseases associated with the central nervous system. Additionally, methods of preparation of substituted N-phenyl-bipyrrolidine carboxamides and intermediates therefor are disclosed.
申请公布号 US8227481(B2) 申请公布日期 2012.07.24
申请号 US201113151946 申请日期 2011.06.02
申请人 GAO ZHONGLI;HALL DANIEL;HARTUNG RYAN;SANOFI 发明人 GAO ZHONGLI;HALL DANIEL;HARTUNG RYAN
分类号 C07D401/04;A61K31/438 主分类号 C07D401/04
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