发明名称 CHELATED MERCURY COMPLEXES WITH CYSTEINE AND METHIONINE, METHOD FOR PREPARING THEM, AND DRUG PREPARATION MERCURID APOPTOSIS MODULATOR SHOWING ANTICANCER, ANTIVIRAL, ANTIPARASITIC AND IMMUNOMODULATING ACTION
摘要 FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention refers to chelated mercury complexes with cysteine of formula C6H13O4N2S2HgCl or methionine of formula C10H21O4N2S2HgCl which show anticancer, antiviral, antiparasitic and immunomodulating action. The invention also concerns a method for preparing the complexes specified above which involves conducting a reaction of mercury dichloride and an aqueous solution of cysteine or methionine, keeping the mixture at temperature 35-40C for 60-90 min, cooling the reaction mixture to 18-20C and setting at this temperature for one day. The invention also refers to a drug preparation that is an apoptosis modulator of showing anticancer, antiviral, immunomodulating and antiparasitic action which contains the chelated mercury complex with cysteine or methionine 0.38-0.52 wt % and distilled water. ^ EFFECT: invention provides preparing the new chelated mercury complexes showing anticancer, antiviral, antiparasitic and immunomodulating action, and also the simplified method for preparing them at lower temperatures. ^ 6 cl, 8 tbl, 8 ex
申请公布号 RU2456001(C2) 申请公布日期 2012.07.20
申请号 RU20100107176 申请日期 2010.02.26
申请人 GUSEV SERGEJ NIKOLAEVICH;GUSEV RUSLAN SERGEEVICH;GRAMMA ALEKSANDR IVANOVICH 发明人 GUSEV SERGEJ NIKOLAEVICH;GUSEV RUSLAN SERGEEVICH;GRAMMA ALEKSANDR IVANOVICH
分类号 A61K31/198;A61K33/28;A61P31/12;A61P33/00;A61P35/00;A61P37/02;C01G13/00 主分类号 A61K31/198
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