PROCESS FOR PRODUCING DOCETAXEL, AND MEDICINE

摘要

PROBLEM TO BE SOLVED: To provide docetaxel having high purity.

SOLUTION: The process comprises: producing 10-deacetyl-7,10-bis-trichloroacetylbaccatin III (VI) having small content of 7- or 10-mono-trichloroacetyl, so as to be 10-deacetyl-N-debenzoyl-paclitaxel (I); and reacting the 10-deacetyl-N-debenzoyl-paclitaxel (I) with di-tert-butyl dicarbonate to obtain the docetaxel having high purity.

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