POLYMERIC IRON CHELATING AGENT

摘要

Disclosed is a water-insoluble polymeric iron chelating agent characterized by having a polymer backbone and an aromatic ring which is bound to the polymer backbone through a bond -NH-CH2-, wherein the aromatic ring has one or two first functional groups each of which is a hydroxy group and one or two second functional groups each of which is selected from a hydroxy group, a carboxylic acid group and a functional group represented by formula (I) [wherein A represents -CH3, -CH2-CH3, -CH2-C6H5, -CH2-C5H4N or -CH2-COOH; and B represents -CH2-COOH], and each of the second functional groups is located at an ortho-position relative to at least one of the first functional groups. This water-insoluble polymeric iron chelating agent has the advantage that the chelating agent can selectively chelate an iron ion, particularly biologically instable iron and that the chelating agent is insoluble in water and therefore cannot be incorporated into a metabolic process in vivo.