Use of the FGF-2 and anosmin-1 proteins for predicting the histopathology of the lesions of a patient suffering from a central nervous system (CNS) demyelinating disease by means of the detection of the amount of said proteins in a sample of isolated biological fluid. Furthermore, the present invention relates to a method for ascertaining the histopathological characteristics of the lesions of a patient suffering from a CNS demyelinating disease and to a kit for implementing said method. Preferably, the CNS demyelinating disease is multiple sclerosis and the biological fluid is cerebrospinal fluid (CSF)..
申请公布号
EP2477030(A2)
申请公布日期
2012.07.18
申请号
EP20100763733
申请日期
2010.09.07
申请人
FUNDACION DEL HOSPITAL NACIONAL DE PARAPLEJICOS PARA LA INVESTIGACION Y LA INTEGRACION
发明人
DE CASTRO SOUBRIET, FERNANDO;CLEMENTE LOPEZ, DIEGO;ORTEGA MUNOZ, MARIA CRISTINA;ARENZANA SANAGERICO, FRANCISCO JAVIER