发明名称 |
Six-membered N-heterocyclic carbene-based catalysts for asymmetric reactions |
摘要 |
The present invention provides a catalyst complex or ligand, and compositions thereof, for use in a variety of organic reactions having high reactivity and enantioselectivity. The catalyst is a N-heterocyclic carbene having three fused rings with first and second rings being six-membered rings and the third being a five-membered ring. The first ring is fused to the second and has four substituents. The second ring has two nitrogens flanking a carbene atom with one nitrogen bound to a substituent. The carbene atom may optionally be bonded to a metal. The third ring is fused to the second ring and contains two nitrogens. The third ring of the catalyst has a double bond and two substituents on adjacent non-fused carbons. A non-fused nitrogen of the third ring is partially bonded to another substituent. Methods for the synthesis and use of the catalyst embodiments of the present invention are also provided. |
申请公布号 |
US8222265(B2) |
申请公布日期 |
2012.07.17 |
申请号 |
US20100870901 |
申请日期 |
2010.08.30 |
申请人 |
MCQUADE D. TYLER;PARK JIN KYOON;REXFORD MATTHEW D.;LACKEY HERSHEL H.;FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION |
发明人 |
MCQUADE D. TYLER;PARK JIN KYOON;REXFORD MATTHEW D.;LACKEY HERSHEL H. |
分类号 |
A01N43/54;A61K31/505;C07D239/00;C07D487/00 |
主分类号 |
A01N43/54 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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