发明名称 |
STABLE POLYPEPTIDE FORMULATIONS |
摘要 |
The invention provides a formulation including a buffer having a pH less than 6.0, a divalent cation between about 5-200 mM, an excipient comprising a sugar or polyol and an effective amount of a therapeutic polypeptide. Also provided is a method of stabilizing a polypeptide. The method includes contacting a therapeutic polypeptide with a concentration of divalent cation between about 5-150 150 mM in a buffer having a pH less than 6.0 and an excipient comprising a sugar or polyol.
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申请公布号 |
CA2666492(C) |
申请公布日期 |
2012.07.17 |
申请号 |
CA20072666492 |
申请日期 |
2007.10.05 |
申请人 |
AMGEN INC. |
发明人 |
REHDER, DOUGLAS;BONDARENKO, PAVEL;CHELIUS, DIRK;MCAULEY, ARNOLD;MATSUMURA, MASAZUMI |
分类号 |
A61K47/02;A61K9/08;A61K39/395;A61K47/26 |
主分类号 |
A61K47/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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