发明名称 |
METHOD OF IDENTIFYING RESPONDERS TO TREATMENT WITH INSULIN SENSITIZERS |
摘要 |
A patient who is a responder to a therapeutic treatment for insulin resistance or for one or more diseases associated with type 2 diabetes can be identified by the method of measuring the amount of HMW adiponectin and the amount of total adiponectin or LMW adiponectin in the patient~s tissue (usually plasma or serum) before the therapeutic treatment commences; then commencing the therapeutic treatment; and finally measuring the amount of HMW adiponectin and the amount of either total adiponectin or LMW adiponectin in the patient~s plasma or serum one or more times after commencement of the therapeutic treatment. The patient is predicted to be a responder to the therapeutic treatment if the ratio of the amount of HMW adiponectin to the amount of total adiponectin or LMW adiponectin increases after the therapeutic treatment commences.
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申请公布号 |
CA2545065(C) |
申请公布日期 |
2012.07.17 |
申请号 |
CA20042545065 |
申请日期 |
2004.11.04 |
申请人 |
MERCK & CO., INC.;ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY |
发明人 |
WAGNER, JOHN A.;SCHERER, PHILIPP E.;PAJVANI, UTPAL B. |
分类号 |
G01N33/74;A61K49/00;G01N33/53;G01N33/68 |
主分类号 |
G01N33/74 |
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