发明名称 |
Compounds for proteasome enzyme inhibition |
摘要 |
Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by the compounds described. For example, the chymotrypsin-like activity of the 20S proteasome may be selectively inhibited with the inventive compounds. The peptide-based compounds include an epoxide or aziridine, and functionalization at the N-terminus. Among other therapeutic utilities, the peptide-based compounds are expected to display anti-inflammatory properties and inhibition of cell proliferation. |
申请公布号 |
AU2005271232(B2) |
申请公布日期 |
2012.07.05 |
申请号 |
AU20050271232 |
申请日期 |
2005.08.08 |
申请人 |
PROTEOLIX, INC. |
发明人 |
SMYTH, MARK S.;LAIDIG, GUY J. |
分类号 |
C07K5/087;A61K38/00;A61K38/04;A61K38/06;A61K38/07;C07K5/02;C07K5/04;C07K5/10;C07K5/103;C07K5/107 |
主分类号 |
C07K5/087 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|