METHODS OF RAISING AN IMMUNE RESPONSE BY DELIVERY OF RNA
摘要
RNA encoding an immunogen is co-delivered to non-immune cells at the site of delivery and also to immune cells which infiltrate the site of delivery. The responses of these two cell types to the same delivered RNA lead to two different effects, which interact to produce a strong immune response against the immunogen. The non-immune cells translate the RNA and express the immunogen. Infiltrating immune cells respond to the RNA by expressing type I interferons and pro-inflammatory cytokines which produce a local adjuvant effect which acts on the immunogen-expressing non-immune cells to upregulate major histocompatibility complex expression, thereby increasing presentation of the translated protein to T cells. The effects on the immune and non-immune cells can be achieved by a single delivery of a single RNA e.g. by a single injection.
申请公布号
WO2012006377(A3)
申请公布日期
2012.07.05
申请号
WO2011US43104
申请日期
2011.07.06
申请人
NOVARTIS AG;GEALL, ANDREW;RAMSAUER, KATRIN;OTTEN, GILLIS;MANDL, CHRISTIAN
发明人
GEALL, ANDREW;RAMSAUER, KATRIN;OTTEN, GILLIS;MANDL, CHRISTIAN