发明名称 |
RETRO-INVERSO PEPTIDES DERIVED FROM INTERLEUKIN-6 |
摘要 |
This invention provides methods of treatment using retro-inverso peptides derived from interleukin-6 (IL-6) having between 15 and about 40 amino acids, and including the sequence that is retro-inverso with respect to SEQ ID NO 1, i.e. wherein said peptide comprises the sequence D-Glu-D-Ala-D-Met-D-Lys-D-Pro-D-Leu-D-Asn-D-Leu-D-Asn-D-Asn-D-Glu-D-Ala-D-Leu-D-Ala-D-Glu. The peptides of the invention have the same activity as native IL-6 and also have neurotrophic activity. The peptides of the invention are also less susceptible to proteolytic degradation in vivo because of their D-amino acid linkage. |
申请公布号 |
US2012172305(A1) |
申请公布日期 |
2012.07.05 |
申请号 |
US201113284617 |
申请日期 |
2011.10.28 |
申请人 |
WRIGHT DAVID E.;PARKS D. ELLIOT;MYELOS CORPORATION |
发明人 |
WRIGHT DAVID E.;PARKS D. ELLIOT |
分类号 |
A61K38/17;A61K38/10;A61P7/00;C12N5/02 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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地址 |
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