| 摘要 |
The environmental factor and causal agent of the cervicouterine cancer is the persistent infection by HPV of high risk, associated to unknown genetic factors. The use of a genetic variant Q/Q of AKNA is proposed for indentifying individuals with high risks of HPV infection and development of CUCa. The AKNA gene encodes for a protein which acts as a transcriptional activator for inducing the expression of co-activating molecules of the cellular immune response intended to remove the viral infections. The AKNA gene has three genetic variants, the first being the homozygous variant RIR, the second being the homozygous Q/Q, and the third being the homozygous R/Q. It has been identified that the individuals carrying the homozygous version Q/Q are susceptible to develop persistence in the HPV infection of high risk and consequently developing CUCa. In Mexico, a woman dies every two hours of CUCa and annually it has been identified 11,000 new cases of women affected by this disease. Consequently, the generation of a test for identifying women carrying this variant of AKNA gene will be useful as an early identification diagnosis method in these women having a high risk of developing CUCa..
|
