发明名称 |
HUMAN ARTIFICIAL CHROMOSOME CONTAINING HUMAN ANTIBODY .LAMBDA. LIGHT CHAIN GENE AND NON-HUMAN ANIMAL CONTAINING THE HUMAN ARTIFICIAL CHROMOSOME CAPABLE OF GENETIC TRANSMISSION |
摘要 |
The present invention relates to a human artificial chromosome which is genetically transmissible to the next generation with high efficiency and the method for using the same. More specifically, the present invention relates to: a human artificial chromosome in which an about 3.5 Mb to about 1 Mb region containing an antibody .lambda. light chain gene derived from human chromosome 22 is bound to a chromosome fragment which is transmissible to a progeny through a germ line of a non-human animal, said chromosome fragment is derived from another human chromosome; a non-human animal carrying the human artificial chromosome and an offspring thereof; a method for producing the non-human animal; a method for producing a human antibody using the non-human animal or an offspring thereof; and a human antibody producing mouse carrying the human artificial chromosome. |
申请公布号 |
CA2446968(C) |
申请公布日期 |
2012.07.03 |
申请号 |
CA20022446968 |
申请日期 |
2002.05.10 |
申请人 |
KIRIN BEER KABUSHIKI KAISHA;MEDAREX, INC. |
发明人 |
KUROIWA, YOSHIMI;TOMIZUKA, KAZUMA;YOSHIDA, HITOSHI;ISHIDA, ISAO |
分类号 |
A01K67/027;C12N15/09;A61K48/00;C07K16/00;C07K16/24;C12N5/12;C12N15/02;C12N15/13;C12N15/85;C12N15/87;C12N15/90;C12P21/00;C12P21/08 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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