METHOD OF PRODUCING OLMESARTAN MEDOXOMIL AND TABLET THEREOF

摘要

PURPOSE: A novel method for preparing olmesartan medoxomil is provided to enhance yield and to enable easy production of a finished product without pulverization. CONSTITUTION: A method for preparing olmesartan mesoxomil comprises: a step of (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2'-(1-trityl-1H-tetrazole-5-yl)biphenyl-4-yl)methyl)-1H-imidazole-5-carboxylate in a mixture solvent of water and acetic acid to preparing (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 1-((2'-(1H-tetrazole-5-yl)biphenyl-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate(olesartan medoxomil).