AN ANTI-CD6 MONOCLONAL ANTIBODY AND A METHOD THEREOF

摘要

A monoclonal antibody that comprises a heavy chain polypeptide and a light chain polypeptide of SEQ ID NOs: 1 and 2 respectively. The mAb binds domain 1 (D1) of CD6 and inhibits T cell proliferation without interfering with ALCAM binding. The mAb can be used to treat auto-immune disorders selected from multiple sclerosis, transplant rejection, type-1 diabetes, rheumatoid arthritis, psoriasis and T-cell mediated auto-immune disorders.