METHOD FOR ULTRASOUND CONTROLLED RELEASING MEDICINE-CARRYING CONTRAST MICRO-BUBBLES AND MONITOR-IMAGING THEREOF AND METHOD FOR ESTIMATING DAMAGED QUANTITY OF MICROBUBBLES

摘要

A method for ultrasound controlled releasing medicine-carrying contrast micro-bubbles and monitor-imaging thereof and a method for estimating damaged quantity of micro-bubbles. According to the method for ultrasound controlled releasing medicine-carrying micro-bubbles and monitor-imaging thereof, the medicine-carrying contrast micro-bubbles are controlled to locally, point-fixedly and shape-fittingly release on the basis of the present full-digitized ultrasound imaging system, and the micro-bubbles before and after releasing the medicine in the focus region are monitored via monitor-imaging of low-energy encoded excitation, and then the released quantity of the medicine is estimated on the basis of the radio frequency echo data of the monitor-imaging and the change of the concentration of the scattering phonons. According to the method for estimating damage quantity of micro-bubbles, a time-parameter m curve of the region of interest is drawn by imaging the parameter m of Nakagami statistical model, and the decrement of the micro-bubbles is analyzed on the basis of the curve to determine the released quantity of the medicine in the region.