SINGLE NUCLEOTIDE POLYMORPHISMS AND GENES ASSOCIATED WITH T2D-RELATED COMPLICATIONS

摘要

The invention provides with means to predict, in subjects affected by type-2-diabetes (T2D), the probability of developing compiications related to the disease. The invention involves (1) identification of genetic features such as single nucleotide polymorphisms (SNPs) for the establishment of a patient profile that can be used for prediction of complications associated with T2D. Signature profiles comprising a combination of SNPs which have greater predictive value for prognosticating particular types of complications, such as, stroke, myocardial infai'ction and kidney complications associated with T2D are further described. Compositions and kits that can be used with a set of complementary phenoiypic markers to evaluate the risk for an individual affected by T2D to develop complications related to the disease and to evaluate the likelihood that an individual affected by type 2 diabetes type will benefit from treatments that collectively aim to reduce the risk of developing such complications.