| 摘要 |
Compounds of formula I:
wherein:
R 2 is hydrogen or C 1 -C 4 alkyl;
R 3 and R 4 are hydrogen, -C(=O)R 5 , or -C(=O)CHR 6 -NH 2 ; or
R 3 is hydrogen and R 4 is a monophosphate-, diphosphate-, or triphosphate ester; or R 3 is hydrogen, -C(=O)CHR 5 , or -C(=O)CHR 6 -NH 2 and R 4 is
each R 5 is hydrogen, C 1 -C 6 alkyl, or C 3 -C 7 cycloalkyl;
R 6 is hydrogen or C 1 -C 6 alkyl;
R 7 is optionally substituted phenyl; naphthyl; or indolyl;
R 8 and R 8' are hydrogen, C 1 -C 6 alkyl, benzyl; or
R 8 and R 8' combined form C 3 -C 7 cycloalkyl;
R 9 is C 1 -C 6 alkyl, benzyl, or optionally substituted phenyl;
provided that R 2 , R 3 and R 4 are not all hydrogen;
or a pharmaceutically acceptable salt or solvate thereof;
pharmaceutical formulations with the compounds I; the use of compounds I, including the compounds of formula I wherein R 2 , R 3 and R 4 are all hydrogen, as HCV inhibitors. |
