MicroRNA-based methods and compositions for the diagnosis and treatment of pancreatic cancer

摘要

The present invention provides novel methods for the diagnosis of pancreatic cancer. The methods comprise measuring the levels of a group of miR gene products consisting of miR-103-1, miR-103-2, miR-155 and miR-204, wherein an increase in the level of miR-103-1, miR-103-2 and miR-204 gene product in the test sample and a decrease in the level of miR-155 gene product in the test sample, relative to the levels of the corresponding miR gene products in a control sample, is indicative of the subject having pancreatic cancer.