发明名称 NEPRILYSIN INHIBITORS
摘要 In one aspect, the invention relates to compounds having the formula: where R1-R6, a, b, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
申请公布号 US2012157386(A1) 申请公布日期 2012.06.21
申请号 US201113325453 申请日期 2011.12.14
申请人 THERAVANCE, INC. 发明人 SMITH CAMERON;FLEURY MELISSA;GENDRON ROLAND;HUDSON RYAN;HUGHES ADAM D.
分类号 A61K31/415;A61K31/42;A61K31/4439;A61K31/5377;A61K31/704;A61K38/02;A61P1/12;A61P3/06;A61P3/10;A61P7/02;A61P7/10;A61P9/04;A61P9/12;A61P13/12;A61P21/02;A61P25/00;A61P27/06;A61P29/00;C07C229/34;C07C271/08;C07D231/14;C07D401/06;C07D413/06 主分类号 A61K31/415
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